Linda Lan

Linda Lan

Immunologist, DVM & PhD · Co-founder of Muno.

I'm a postdoctoral research fellow in the Department of Genetics at Stanford University School of Medicine (Snyder Lab), studying B-cell immunology at the intersection of wearable technology and multi-omics analysis.

My core work pairs smartwatches with at-home microsampling to build longitudinal molecular profiles, aiming to identify biomarkers for post-acute infection syndromes such as long COVID, ME/CFS, and PTLDS. I'm also interested in vaccines and antibody responses to infectious diseases. Earlier, my doctoral research at the University of Chicago helped uncover broadly neutralizing antibodies against influenza, published in Immunity, Nature, and Science Translational Medicine.

I'm a co-founder of Muno Biotech, alongside Dr. Michael Snyder and Jo Teichmann, translating this research into personalized health testing for chronic illness.

Research

I research B-cell immunology with a focus on the intersection of wearable devices and multi-omics analysis. Using smartwatches and microsampling to collect longitudinal data, I work to identify biomarkers for post-acute infection syndromes, and I build accessible software so others can analyze the B-cell receptor repertoire without a computational background.

Longitudinal analyses of long COVID, ME/CFS & PTLDS using wearables and microsampling

Stanford University, Snyder Lab · Combining smartwatch data and at-home microsampling to build longitudinal molecular profiles of post-acute infection syndromes and surface candidate biomarkers.

Clono: a B-cell receptor analysis app

Stanford University · A user-friendly application for B-cell receptor (BCR) repertoire analysis, making complex immunological data accessible to researchers and clinicians.

Autoantibodies and cognitive decline in long COVID

Lead author · Exploring the association between autoantibody profiles and cognitive symptoms in long COVID patients.

DN2 B cells drive autoantibody production in SARS-CoV-2 infection via TLR7 and T-bet/XBP1

Co-author · Submitted to Immunity (in revision). Mechanisms of autoantibody generation following SARS-CoV-2 infection.

Grants & Fellowships

AAI Intersect Fellowship for Computational Scientists and Immunologists

$55,632 · American Association of Immunologists.

Stanford ITI & SAAS Seed Grant  · Co-Investigator

$80,000 · Stanford Institute for Immunity, Transplantation and Infection (ITI) & Stanford Autoimmunity & Allergy Supergroup (SAAS).

Selected Publications

Long-lasting B cell convergence to distinct broadly reactive epitopes following vaccination with chimeric influenza virus hemagglutinins

Immunity · Guthmiller J*, Lan LY*, Li L*, et al. (co-first author) · DOI: 10.1016/j.immuni.2025.02.025

Broadly neutralizing antibodies target a haemagglutinin anchor epitope

Nature · Guthmiller JJ, Han J, Utset HA, Li L, Lan LY, et al. · DOI: 10.1038/s41586-021-04356-8

Improved integration of single-cell transcriptome and surface protein expression by LinQ-View

Cell Reports Methods · Li L, Dugan HL, Stamper CT, Lan LY, et al. · DOI: 10.1016/j.crmeth.2021.100056

Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans

Science Translational Medicine · Dugan HL, Guthmiller JJ, et al., Lan LY, et al. · DOI: 10.1126/scitranslmed.abd3601

Understanding memory B cell responses to a chimeric-based universal influenza virus vaccine candidate

The Journal of Immunology · Lan LY, Li L, Huang M, et al. (first author)

Influenza infection in humans induces broadly cross-reactive and protective neuraminidase-reactive antibodies

Cell · Chen YQ, Wohlbold TJ, et al., Lan LY, et al. · DOI: 10.1016/j.cell.2018.03.030

Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation

Science Immunology · Lau D*, Lan LY*, Andrews S, et al. (co-first author) · DOI: 10.1126/sciimmunol.aai8153

Biomarkers in precision medicine  · Book chapter

Lan LY, Kumar W, Liu LS, Roberts A, Chen S, Snyder M. Pages 35–57.

See full publication list in CV →

Education

Postdoctoral Research Fellow, Genetics  · Stanford University School of Medicine

Palo Alto, CA · Snyder Lab. B-cell immunology, wearables, and multi-omics for post-acute infection syndromes.

Ph.D. in Immunology  · University of Chicago

Chicago, IL · Universal influenza vaccine development and broadly neutralizing antibody responses (Wilson Lab).

M.Sc.  · National Taiwan University

Taipei, Taiwan · Thesis on granulysin expression in a humanized mouse model of xenogeneic graft-versus-host disease.

Doctor of Veterinary Medicine (DVM)  · National Chung Hsing University

Taichung, Taiwan · Licensed veterinarian, Taiwan (2009).

Awards & Honors

AAI Intersect Fellowship for Computational Scientists and Immunologists

$55,632 · American Association of Immunologists.

AAI Trainee Abstract Award

American Association of Immunologists.

CEIRS Training Award

$6,000 · Centers for Excellence in Influenza Research and Surveillance.

Studying Abroad Scholarship

$32,000 · Government of Taiwan.

Outstanding Reviewer, International Immunopharmacology  · Elsevier

Phi Tau Phi Scholastic Honor Society Scholarship (2019) · AAI Advanced Course in Immunology certificate (2017).

Teaching & Mentoring

Research Mentor  · Stanford University

Mentored 10+ students across master's, medical, undergraduate, and high-school levels on projects in computational biology, BCR analysis, long COVID research, and machine learning.

Teaching Assistant, Experimental Immunology  · University of Chicago

Led laboratory sessions and mentored undergraduate students.

Teaching Assistant, Veterinary Anatomy  · National Taiwan University

Taipei, Taiwan.

Leadership & Service

President, Taiwanese Student Association  · University of Chicago

Received the William J. Michel Award, the most distinguished annual award for a student organization's contribution to the campus community.

Co-organizer, Midwest Taiwanese Biotechnology Symposium  · University of Chicago

Organized a regional symposium connecting biotechnology researchers across the Midwest.

Workshop Leader, Expanding Your Horizons  · Chicago

Science education outreach encouraging young women in STEM.